Shadows of Sanctuary
Vampiric hybrids were the creations of Hannibal Church during his siring to Desmond Faust. Monstrous beasts infused with vampiric blood and dark magic, Church's vampiric hybrids were living vampires, effectively vampiric monsters with beating hearts and warm flesh. These beasts possessed the preternatural strength and agility, heightened senses, and insatiable bloodlust of Hannibal Church himself, but with no vulnerabilities to light, silver, divine power, or garlic.
During his uprising against his master, Church equipped these hybrids with silver prosthetic weapons, commanding them to slay Faust on sight.